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GlyH-101

Catalog No.: 16123006
Cas No.: 328541-79-3
Purity : 98% 
16123006 - GlyH-101 | CAS 328541-79-3

Catalog number : 16123006

CAS number : 328541-79-3

分子式 : C19H15Br2N3O3 

分子量 : 493.15 

Iupac 化学名称 : GlyH-101 

Smile : c1ccc2cc(ccc2c1)NCC(=O)N/N=C/c3cc(c(c(c3O)Br)O)Br

InChiKey : RMBDLOATEPYBSI-NUGSKGIGSA-N

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同义词GlyH101; GlyH 101 
英文同义词GlyH101; GlyH 101 
分子式C19H15Br2N3O3 
分子量493.15 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1ccc2cc(ccc2c1)NCC(=O)N/N=C/c3cc(c(c(c3O)Br)O)Br
InChiKeyRMBDLOATEPYBSI-NUGSKGIGSA-N
InChiInChI=1S/C19H15Br2N3O3/c20-15-8-13(18(26)17(21)19(15)27)9-23-24-16(25)10-22-14-6-5-11-3-1-2-4-12(11)7-14/h1-9,22,26-27H,10H2,(H,24,25)/b23-9+
MDLMFCD01532954
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GlyH-101 is a CFTR inhibitor (cystic fibrosis transmembrane conductance regulator). GlyH-101 is a glycine hydrazide that has been shown to block CFTR channels. GlyH-101 blocked I(Cl.PKA) in a concentration- and voltage-dependent fashion (IC(50) at +100 mV=0.3 Â 1.5 M and at -100 mV=5.1 Â 1.3 M). GlyH-101 blocks the open pore of cardiac CFTR channels at an electrical distance of 0.15 Â 0.03 from the external membrane surface. 

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