GW4064
编号: 16071018
Cas号: 278779-30-9
纯度: 98% by HPLC
GW-4064 is a selective agonist of FXR (EC50 = 15 nM).2 It displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 M. GW-4064 upregulates adipokine expression in preadipocytes and HepG2 cells. GW4064 could reduce induction of proinflammatory cytokines by LPS in vitro.
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化学信息
| 名称 | GW4064 |
|---|---|
| Iupac 化学名称 | 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-benzoic acid |
| 同义词 | GW4064; GW-4064 |
| 英文同义词 | GW4064; GW-4064 |
| 分子式 | C28H22Cl3NO4 |
| 分子量 | 542.837 |
| Smile | ClC1=C(C=CC(=C1)OCC=1C(=NOC1C(C)C)C1=C(C=CC=C1Cl)Cl)C=CC=1C=C(C(=O)O)C=CC1 |
| InChiKey | BYTNEISLBIENSA-UHFFFAOYSA-N |
| InChi | InChI=1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34) |
| Cas号 | 278779-30-9 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
