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GW 627368

Catalog No.: 91003
Cas No.: 439288-66-1
Purity : 98% 
91003 - GW 627368 | CAS 439288-66-1

Catalog number : 91003

CAS number : 439288-66-1

分子式 : C30H28N2O6S 

分子量 : 544.6 

化学名称 : GW 627368

Smile : CCOc1c2ccccc2c(c3c1CN(C3=O)c4ccc(cc4)CC(=O)NS(=O)(=O)c5ccccc5)OCC

InChiKey : XREWXJVMYAXCJV-UHFFFAOYSA-N

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同义词4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide 
英文同义词4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide 
分子式C30H28N2O6S 
分子量544.6 
外观Crystalline Solid 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCCOc1c2ccccc2c(c3c1CN(C3=O)c4ccc(cc4)CC(=O)NS(=O)(=O)c5ccccc5)OCC
InChiKeyXREWXJVMYAXCJV-UHFFFAOYSA-N
InChiInChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33)
MDLMFCD12912327
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GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human EP4 and TP receptors with Ki values of 100 nM and 158 nM, respectively. Affinity for all other human prostanoid receptors is >5.0 M. In human washed platelets, GW 627368X produced 100% inhibition of U-46619 (EC100)-induced aggregation at a concentration of 10 M. 

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