GSK2801 is a A Selective Chemical Probe for BAZ2B/A bromodomains. BAZ2A/B belong to a family of ubiquitously expressed bromodomain containing proteins. Proteins of the BAZ family are characterized by a carboxy-terminal bromodomain adjacent to a PHD finger and a WACZ motif. In addition four other conserved motifs are typically found in the N-terminus of BAZ family members, namely the LH motif (a leucine-rich helical domain), the ZB2 motif and the BAZ 1 and BAZ 2 motifs. Little is known about the biological function of BAZ2B but it has been suggested to regulate nucleosome mobilization by the ATP-dependent chromatin remodeling factor ISWI. (http://www.thesgc.org/chemical-probes/GSK2801).
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化学信息
| 名称 | GSK2801 |
| Iupac 化学名称 | GSK2801 |
| 同义词 | GSK-2801; GSK 2801 |
| 英文同义词 | GSK-2801; GSK 2801 |
| 分子式 | C20H21NO4S |
| 分子量 | 371.45004 |
| Smile | CS(=O)(=O)C1=C(C=CC=C1)C1=C2C=C(C=CN2C(=C1)C(C)=O)OCCC |
| InChiKey | KHWCPNJRJCNVRI-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3 |
| Cas号 | 1619994-68-1 |
| 相关CAS号 | |
| 外观性状 | crystalline solid |
| 纯度 | 98% |
| 存储 | 3 years -20ºCpowder |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
| 海关编码 | |
| Targets | |
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |