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GSK1904529A

Catalog No.: 121428
Cas No.: 1089283-49-7
Purity :
121428 - GSK1904529A | CAS 1089283-49-7

Catalog number : 121428

CAS number : 1089283-49-7

分子式 : C44H47F2N9O5S 

分子量 : 851.963 

Iupac 化学名称 : N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamide 

Smile : FC1=C(C(=CC=C1)F)NC(C1=C(C=CC(=C1)C=1N=C2N(C=CC=C2)C1C1=NC(=NC=C1)NC1=C(C=C(C(=C1)CC)N1CCC(CC1)N1CCN(CC1)S(=O)(=O)C)OC)OC)=O

InChiKey : MOSKATHMXWSZTQ-UHFFFAOYSA-N

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同义词GSK-1904529A; GSK 1904529A 
英文同义词GSK-1904529A; GSK 1904529A 
分子式C44H47F2N9O5S 
分子量851.963 
外观Solid powder 
可溶性Soluble in DMSO 
运输条件Shipped under ambient temperature 
SmileFC1=C(C(=CC=C1)F)NC(C1=C(C=CC(=C1)C=1N=C2N(C=CC=C2)C1C1=NC(=NC=C1)NC1=C(C=C(C(=C1)CC)N1CCC(CC1)N1CCN(CC1)S(=O)(=O)C)OC)OC)=O
InChiKeyMOSKATHMXWSZTQ-UHFFFAOYSA-N
InChiInChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49)
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GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, >100-fold more selective for IGF-1R/InsR than Akt1/2, Aurora A/B,B-Raf, CDK2, EGFR etc. 

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