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GSK1210151A

Catalog No.: 16070808
Cas No.: 1300031-49-5
Purity : 98% by HPLC 
16070808 - GSK1210151A | CAS 1300031-49-5

Catalog number : 16070808

CAS number : 1300031-49-5

分子式 : C23H21N5O3 

分子量 : 415.44 

Iupac 化学名称 : 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one 

Smile : CC1=NOC(=C1C=1C(=CC=2C3=C(C=NC2C1)NC(N3[C@H](C)C3=NC=CC=C3)=O)OC)C

InChiKey : VUVUVNZRUGEAHB-CYBMUJFWSA-N

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同义词IBET151; IBET-151; 
英文同义词IBET151; IBET-151; 
分子式C23H21N5O3 
分子量415.44 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCC1=NOC(=C1C=1C(=CC=2C3=C(C=NC2C1)NC(N3[C@H](C)C3=NC=CC=C3)=O)OC)C
InChiKeyVUVUVNZRUGEAHB-CYBMUJFWSA-N
InChiInChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
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 GSK1210151A, also known as I-BET151, is a BET bromodomain inhibitor, which blocks recruitment of BET to chromatin. I-BET151 ( GSK1210151A ) shows good oral bioavailability in both the rat and minipig as well as demonstrating efficient suppression of bacterial induced inflammation and sepsis in a murine in vivo endotoxaemia model.  

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