GSK0660
编号: 16123009
Cas号: 1014691-61-2
纯度: 98%
GSK0660 is a selective PPAR antagonist. GSK0660 differentially regulated 273 transcripts in TNF-treated cells compared to TNF alone. A pathway analysis revealed the enrichment of cytokine-cytokine receptor signaling. In particular, GSK0660 blocks the TNF-induced upregulation of CCL8, a chemokine involved in leukocyte recruitment. GSK0660 blocks the effect of TNF on the expressions of cytokines involved in leukocyte recruitment, including CCL8, CCL17, and CXCL10 and it may therefore block TNF-induced retinal leukostasis.
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化学信息
| 名称 | GSK0660 |
|---|---|
| Iupac 化学名称 | GSK0660 |
| 同义词 | GSK-0660; GSK 0660 |
| 英文同义词 | GSK-0660; GSK 0660 |
| 分子式 | C19H18N2O5S2 |
| 分子量 | 418.48 |
| Smile | COc1cc(ccc1NS(=O)(=O)c2ccsc2C(=O)OC)Nc3ccccc3 |
| InChiKey | NDFKBGWLUHKMFY-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3 |
| Cas号 | 1014691-61-2 |
| MDL | MFCD12828770 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
