GSK-690693
编号: 161009019
Cas号: 937174-76-0
纯度: 98% by HPLC
Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport. Check for active clinical trials or closed clinical trials using this agent.
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化学信息
| 名称 | GSK-690693 |
|---|---|
| Iupac 化学名称 | (S)-4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol |
| 同义词 | GSK690693; GSK-690693; GSK 690693 |
| 英文同义词 | GSK690693; GSK-690693; GSK 690693 |
| 分子式 | C21H27N7O3 |
| 分子量 | 425.48418 |
| Smile | NC=1C(=NON1)C=1N(C2=C(C(=NC=C2OC[C@@H]2CNCCC2)C#CC(C)(O)C)N1)CC |
| InChiKey | KGPGFQWBCSZGEL-ZDUSSCGKSA-N |
| InChi | InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 |
| Cas号 | 937174-76-0 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
