GDC-0994
编号: 16062801
Cas号: 1453848-26-4
纯度: 98% by HPLC
GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Check for active clinical trials or closed clinical trials using this agent
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | GDC-0994 |
|---|---|
| Iupac 化学名称 | (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one |
| 同义词 | GDC0994; GDC-0994 |
| 英文同义词 | GDC0994; GDC-0994 |
| 分子式 | C21H18ClFN6O2 |
| 分子量 | 440.86 |
| Smile | ClC1=C(C=C(C=C1)[C@@H](CO)N1C(C=C(C=C1)C1=NC(=NC=C1)NC1=CC=NN1C)=O)F |
| InChiKey | RZUOCXOYPYGSKL-GOSISDBHSA-N |
| InChi | InChI=1S/C21H18ClFN6O2/c1-28-19(5-8-25-28)27-21-24-7-4-17(26-21)13-6-9-29(20(31)11-13)18(12-30)14-2-3-15(22)16(23)10-14/h2-11,18,30H,12H2,1H3,(H,24,26,27)/t18-/m1/s1 |
| Cas号 | 1453848-26-4 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
