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GDC-0994

Catalog No.: 16062801
Cas No.: 1453848-26-4
Purity : 98% by HPLC 
16062801 - GDC-0994 | CAS 1453848-26-4

Catalog number : 16062801

CAS number : 1453848-26-4

分子式 : C21H18ClFN6O2 

分子量 : 440.86 

Iupac 化学名称 : (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 

Smile : ClC1=C(C=C(C=C1)[C@@H](CO)N1C(C=C(C=C1)C1=NC(=NC=C1)NC1=CC=NN1C)=O)F

InChiKey : RZUOCXOYPYGSKL-GOSISDBHSA-N

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同义词GDC0994; GDC-0994 
英文同义词GDC0994; GDC-0994 
分子式C21H18ClFN6O2 
分子量440.86 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileClC1=C(C=C(C=C1)[C@@H](CO)N1C(C=C(C=C1)C1=NC(=NC=C1)NC1=CC=NN1C)=O)F
InChiKeyRZUOCXOYPYGSKL-GOSISDBHSA-N
InChiInChI=1S/C21H18ClFN6O2/c1-28-19(5-8-25-28)27-21-24-7-4-17(26-21)13-6-9-29(20(31)11-13)18(12-30)14-2-3-15(22)16(23)10-14/h2-11,18,30H,12H2,1H3,(H,24,26,27)/t18-/m1/s1
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GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Check for active clinical trials or closed clinical trials using this agent 

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