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GDC-0810(Brilanestrant,ARN-810)

Catalog No.: 90731
Cas No.: 1365888-06-7
Purity : 98% by HPLC 
90731 - GDC-0810(Brilanestrant,ARN-810) | CAS 1365888-06-7

Catalog number : 90731

CAS number : 1365888-06-7

分子式 : C26H20ClFN2O2 

分子量 : 446.90 

Iupac 化学名称 : (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid 

Smile : O=C(O)/C=C/C1=CC=C(/C(C2=CC3=C(NN=C3)C=C2)=C(C4=CC=C(F)C=C4Cl)/CC)C=C1

InChiKey : BURHGPHDEVGCEZ-KJGLQBJMSA-N

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同义词Brilanestrant;GDC-0810;GDC 0810;GDC0810;ARN-810;ARN 810;ARN810 
英文同义词Brilanestrant;GDC-0810;GDC 0810;GDC0810;ARN-810;ARN 810;ARN810 
分子式C26H20ClFN2O2 
分子量446.90 
外观crystalline solid 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileO=C(O)/C=C/C1=CC=C(/C(C2=CC3=C(NN=C3)C=C2)=C(C4=CC=C(F)C=C4Cl)/CC)C=C1
InChiKeyBURHGPHDEVGCEZ-KJGLQBJMSA-N
InChiInChI=1S/C26H20ClFN2O2/c1-2-21(22-10-9-20(28)14-23(22)27)26(18-8-11-24-19(13-18)15-29-30-24)17-6-3-16(4-7-17)5-12-25(31)32/h3-15H,2H2,1H3,(H,29,30)(H,31,32)/b12-5+,26-21+
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GDC-0810 (Brilanestrant, ARN-810, RG6046) is a selective estrogen receptor degrader (SERD) that is designed to bind to the estrogen receptor to limit its function. In addition, when SERDs bind to the estrogen receptor, they may be able to change the shape of the receptor in such a way that the cell eliminates it by degradation.

Mechanism of Action / Target

Selective estrogen receptor degrader

 

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