GDC-0152
编号: 16071101
Cas号: 873652-48-3
纯度: 98% by HPLC
GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | GDC-0152 |
|---|---|
| Iupac 化学名称 | (S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide |
| 同义词 | GDC0152; GDC 0152 |
| 英文同义词 | GDC0152; GDC 0152 |
| 分子式 | C25H34N6O3S |
| 分子量 | 498.64 |
| Smile | C1(CCCCC1)[C@@H](C(=O)N1[C@@H](CCC1)C(=O)NC1=C(N=NS1)C1=CC=CC=C1)NC([C@H](C)NC)=O |
| InChiKey | WZRFLSDVFPIXOV-LRQRDZAKSA-N |
| InChi | InChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1 |
| Cas号 | 873652-48-3 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
