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GDC-0152

Catalog No.: 16071101
Cas No.: 873652-48-3
Purity : 98% by HPLC 
16071101 - GDC-0152 | CAS 873652-48-3

Catalog number : 16071101

CAS number : 873652-48-3

分子式 : C25H34N6O3S 

分子量 : 498.64 

Iupac 化学名称 : (S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide 

Smile : C1(CCCCC1)[C@@H](C(=O)N1[C@@H](CCC1)C(=O)NC1=C(N=NS1)C1=CC=CC=C1)NC([C@H](C)NC)=O

InChiKey : WZRFLSDVFPIXOV-LRQRDZAKSA-N

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同义词GDC0152; GDC 0152 
英文同义词GDC0152; GDC 0152 
分子式C25H34N6O3S 
分子量498.64 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC1(CCCCC1)[C@@H](C(=O)N1[C@@H](CCC1)C(=O)NC1=C(N=NS1)C1=CC=CC=C1)NC([C@H](C)NC)=O
InChiKeyWZRFLSDVFPIXOV-LRQRDZAKSA-N
InChiInChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1
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GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. 

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