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G007-LK

编号: 62908
Cas号: 1380672-07-0
纯度: >98% by HPLC 

G007-LK is specific tankyrase 1/2 inhibitor.G007-LK (66) displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50-values of 46 nM and 25 nM, respectively and a cellular IC50-value of 50 nM combined with an excellent pharmacokinetic profile in mice. G007-LK had good oral availability in mice and about a three-hour half-life when administered intravenously, suggesting the compound was sufficiently stable to be a drug candidate.

 

仅供研究使用。 我们不向患者出售。

化学信息

名称G007-LK
Iupac 化学名称(E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)benzonitrile 
同义词G007LK,G007 LK. 
英文同义词G007LK,G007 LK. 
分子式C25H16ClN7O3S 
分子量529.96 
SmileClC1=C(C=CC=C1)N1C(=NN=C1C1=NC=C(C=C1)S(=O)(=O)C)/C=C/C1=NN=C(O1)C1=CC=C(C#N)C=C1
InChiKeyHIWVLHPKZNBSBE-OUKQBFOZSA-N
InChiInChI=1S/C25H16ClN7O3S/c1-37(34,35)18-10-11-20(28-15-18)24-31-29-22(33(24)21-5-3-2-4-19(21)26)12-13-23-30-32-25(36-23)17-8-6-16(14-27)7-9-17/h2-13,15H,1H3/b13-12+
Cas号1380672-07-0
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状crystalline solid 
纯度>98% by HPLC 
存储-20ºC for 2 years 
可溶性5mg/ml in DMSO 
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

62908 - G007-LK | CAS 1380672-07-0

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