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Foretinib(GSK1363089)

Catalog No.: 51705
Cas No.: 849217-64-7
Purity : 98% 
51705 - Foretinib(GSK1363089) | CAS 849217-64-7

Catalog number : 51705

CAS number : 849217-64-7

分子式 : C34H34F2N4O6 

分子量 : 632.65 

Iupac 化学名称 : N-(3-fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 

Smile : FC=1C=C(C=CC1OC1=CC=NC2=CC(=C(C=C12)OC)OCCCN1CCOCC1)N(C(=O)C1(CC1)C(=O)N)C1=CC=C(C=C1)F

InChiKey : FCGJXAOTZFGHNQ-UHFFFAOYSA-N

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同义词Foretinib,GSK1363089,XL880 
英文同义词Foretinib,GSK1363089,XL880 
分子式C34H34F2N4O6 
分子量632.65 
外观off-white solid 
纯度98% 
可溶性5mg/ml in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature 
SmileFC=1C=C(C=CC1OC1=CC=NC2=CC(=C(C=C12)OC)OCCCN1CCOCC1)N(C(=O)C1(CC1)C(=O)N)C1=CC=C(C=C1)F
InChiKeyFCGJXAOTZFGHNQ-UHFFFAOYSA-N
InChiInChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-39-14-17-44-18-15-39)38-12-9-28(25)46-29-8-7-24(19-26(29)36)40(23-5-3-22(35)4-6-23)33(42)34(10-11-34)32(37)41/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H2,37,41)
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Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFR/ and Tie-2, and little activity to FGFR1 and EGFR. Phase 2. 

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