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Filanesib

Catalog No.: 16071102
Cas No.: 885060-09-3
Purity : 98% by HPLC 
16071102 - Filanesib | CAS 885060-09-3

Catalog number : 16071102

CAS number : 885060-09-3

分子式 : C20H22F2N4O2S 

分子量 : 420.48 

Iupac 化学名称 : (S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide. 

Smile : CN(C(=O)N1[C@](SC(=N1)c2cc(ccc2F)F)(CCCN)c3ccccc3)OC.C(=O)(C(F)(F)F)O

InChiKey : CIJUJPVFECBUKG-BDQAORGHSA-N

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同义词ARRY-520; ARRY 520 
英文同义词ARRY-520; ARRY 520 
分子式C20H22F2N4O2S 
分子量420.48 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCN(C(=O)N1[C@](SC(=N1)c2cc(ccc2F)F)(CCCN)c3ccccc3)OC.C(=O)(C(F)(F)F)O
InChiKeyCIJUJPVFECBUKG-BDQAORGHSA-N
InChiInChI=1S/C20H22F2N4O2S.C2HF3O2/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22;3-2(4,5)1(6)7/h3-5,7-10,13H,6,11-12,23H2,1-2H3;(H,6,7)/t20-;/m0./s1
MDLMFCD23381173
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Filanesib, also known as ARRY-520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis. 

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