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Fezolinetant

Catalog No.: 18722
Cas No.: 1629229-37-3
Purity : >98%

Fezolinetant,也被称为ESN-364,是一种神经kinin-3 (NK-3)受体拮抗剂,已被优化用于妇女健康,并正在被开发用于与性激素相关的疾病,如子宫内膜异位症、多囊卵巢综合征和子宫肌瘤。

For research use only. We do not sell to patients.

Chemical Information

名称Fezolinetant
Iupac 化学名称(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone
同义词Fezolinetant; ESN-364; ESN 364; ESN364
英文同义词Fezolinetant; ESN-364; ESN 364; ESN364
分子式C16H15FN6OS
分子量358.3954
SmileO=C(C1=CC=C(F)C=C1)N2[C@H](C)C3=NN=C(C4=NC(C)=NS4)N3CC2
InChiKeyPPSNFPASKFYPMN-SECBINFHSA-N
InChiInChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1
Cas号1629229-37-3
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Ordering Information

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Formulation 类白色至白色固体
纯度>98%
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO
Handling
运输条件可在常温下运输
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Fraser GL, Ramael S, Hoveyda HR, Gheyle L, Combalbert J. The NK3 Receptor Antagonist ESN364 Suppresses Sex Hormones in Men and Women. J Clin Endocrinol Metab. 2016 Feb;101(2):417-26. doi: 10.1210/jc.2015-3621. Epub 2015 Dec 14. PubMed PMID: 26653113.

2: Fraser GL, Hoveyda HR, Clarke IJ, Ramaswamy S, Plant TM, Rose C, Millar RP. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156(11):4214-25. doi: 10.1210/en.2015-1409. Epub 2015 Aug 25. PubMed PMID: 26305889.


化学结构

18722 - Fezolinetant  | CAS 1629229-37-3

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