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Fevipiprant(NVP-QAW039)

Catalog No.: 16090102
Cas No.: 872365-14-5
Purity : 98% by HPLC/HNMR
16090102 - Fevipiprant(NVP-QAW039) | CAS 872365-14-5

Catalog number : 16090102

CAS number : 872365-14-5

分子式 : C19H17F3N2O4S

分子量 : 426.4

Iupac 化学名称 : 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid

Smile : CC1=C(C=2C(=NC=CC2)N1CC1=C(C=C(C=C1)S(=O)(=O)C)C(F)(F)F)CC(=O)O

InChiKey : GFPPXZDRVCSVNR-UHFFFAOYSA-N

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同义词Fevipiprant;NVP-QAW039;NVPQAW039;NVP QAW039;
英文同义词Fevipiprant;NVP-QAW039;NVPQAW039;NVP QAW039;
分子式C19H17F3N2O4S
分子量426.4
外观类白色固体粉末
纯度98% by HPLC/HNMR
可溶性可溶于DMSO;不溶于水
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
运输条件可在常温下运输
SmileCC1=C(C=2C(=NC=CC2)N1CC1=C(C=C(C=C1)S(=O)(=O)C)C(F)(F)F)CC(=O)O
InChiKeyGFPPXZDRVCSVNR-UHFFFAOYSA-N
InChiInChI=1S/C19H17F3N2O4S/c1-11-15(9-17(25)26)14-4-3-7-23-18(14)24(11)10-12-5-6-13(29(2,27)28)8-16(12)19(20,21)22/h3-8H,9-10H2,1-2H3,(H,25,26)
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Fevipiprant (QAW039) is a T-helper type 2 (CRTh2) receptor antagonists, which is currently in development for the treatment of allergic diseases. 

1. Hardman C, Chen W etc. Fevipiprant, a selective prostaglandin D2 receptor 2 antagonist, inhibits human group 2 innate lymphoid cell aggregation and function. J Allergy Clin Immunol. 2019 Feb 28. pii: S0091-6749(19)30278-7. doi: 10.1016/j.jaci.2019.02.015. [Epub ahead of print]

2. Murillo JC, Dimov V, Gonzalez-Estrada A. An evaluation of fevipiprant for the treatment of asthma: a promising new therapy? Expert Opin Pharmacother. 2018 Dec;19(18):2087-2093. doi: 10.1080/14656566.2018.1540589. Epub 2018 Nov 3.



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