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Fevipiprant ( NVP-QAW039 )

编号: 90102
Cas号: 872365-14-5
纯度: ≧98.0%

Fevipiprant (QAW039; NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.

仅供研究使用。 我们不向患者出售。

化学信息

名称Fevipiprant ( NVP-QAW039 )
Iupac 化学名称2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid
同义词Fevipiprant ; NVP-QAW039 ; NVPQAW039 ; NVP QAW039 ;
英文同义词Fevipiprant ; NVP-QAW039 ; NVPQAW039 ; NVP QAW039 ;
分子式C19H17F3N2O4S
分子量426.4
SmileCC1=C(C=2C(=NC=CC2)N1CC1=C(C=C(C=C1)S(=O)(=O)C)C(F)(F)F)CC(=O)O
InChiKeyGFPPXZDRVCSVNR-UHFFFAOYSA-N
InChiInChI=1S/C19H17F3N2O4S/c1-11-15(9-17(25)26)14-4-3-7-23-18(14)24(11)10-12-5-6-13(29(2,27)28)8-16(12)19(20,21)22/h3-8H,9-10H2,1-2H3,(H,25,26)
Cas号872365-14-5
相关CAS号

订购信息

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外观性状类白色固体粉末
纯度≧98.0%
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
可溶性可溶于DMSO;不溶于水
处理方式
运输条件可在常温下运输
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1. Hardman C, Chen W etc. Fevipiprant, a selective prostaglandin D2 receptor 2 antagonist, inhibits human group 2 innate lymphoid cell aggregation and function. J Allergy Clin Immunol. 2019 Feb 28. pii: S0091-6749(19)30278-7. doi: 10.1016/j.jaci.2019.02.015. [Epub ahead of print]

2. Murillo JC, Dimov V, Gonzalez-Estrada A. An evaluation of fevipiprant for the treatment of asthma: a promising new therapy? Expert Opin Pharmacother. 2018 Dec;19(18):2087-2093. doi: 10.1080/14656566.2018.1540589. Epub 2018 Nov 3.



化学结构

90102 - Fevipiprant ( NVP-QAW039 ) | CAS 872365-14-5

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