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FRAX597

Catalog No.: 72803
Cas No.: 1286739-19-2
Purity : 97% 
72803 - FRAX597 | CAS 1286739-19-2

Catalog number : 72803

CAS number : 1286739-19-2

分子式 : C29H28ClN7OS 

分子量 : 558.10 

Iupac 化学名称 : 6-(2-Chloro-4-thiazol-5-yl-phenyl)-8-ethyl-2-[4-(4-Methyl-piperazin-1-yl)-phenylaMino]-8H-pyrido[2,3-d]pyriMidin-7-one 

Smile : ClC1=C(C=CC(=C1)C1=CN=CS1)C1=CC2=C(N=C(N=C2)NC2=CC=C(C=C2)N2CCN(CC2)C)N(C1=O)CC

InChiKey : DHUJCQOUWQMVCG-UHFFFAOYSA-N

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同义词FRAX 597; FRAX-597 
英文同义词FRAX 597; FRAX-597 
分子式C29H28ClN7OS 
分子量558.10 
外观Solid powder 
纯度97% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileClC1=C(C=CC(=C1)C1=CN=CS1)C1=CC2=C(N=C(N=C2)NC2=CC=C(C=C2)N2CCN(CC2)C)N(C1=O)CC
InChiKeyDHUJCQOUWQMVCG-UHFFFAOYSA-N
InChiInChI=1S/C29H28ClN7OS/c1-3-37-27-20(14-24(28(37)38)23-9-4-19(15-25(23)30)26-17-31-18-39-26)16-32-29(34-27)33-21-5-7-22(8-6-21)36-12-10-35(2)11-13-36/h4-9,14-18H,3,10-13H2,1-2H3,(H,32,33,34)
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FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displayed potent anti-tumor activity in vivo, impairing schwannoma development in an orthotopic model of NF2. These studies identify a novel class of orally available ATP-competitive Group I PAK inhibitors with significant potential for the treatment of NF2 and other cancers. 

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