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FPS-ZM1

Catalog No.: 16123002
Cas No.: 945714-67-0
Purity : 98% 
16123002 - FPS-ZM1 | CAS 945714-67-0

Catalog number : 16123002

CAS number : 945714-67-0

分子式 : C20H22ClNO 

分子量 : 327.852 

Iupac 化学名称 : FPS-ZM1 

Smile : C1C(C(N(C2CCCCC2)CC2C=CC=CC=2)=O)=CC=C(Cl)C=1

InChiKey : XDFKWGIBQMHSOH-UHFFFAOYSA-N

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同义词N/A 
英文同义词N/A 
分子式C20H22ClNO 
分子量327.852 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileC1C(C(N(C2CCCCC2)CC2C=CC=CC=2)=O)=CC=C(Cl)C=1
InChiKeyXDFKWGIBQMHSOH-UHFFFAOYSA-N
InChiInChI=1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2
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FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid- binding to RAGE, neurological damage and inflammation in the APP(sw/0) transgenic mouse model of AD. FPS-ZM1 is not toxic to mice and can easily cross the blood-brain barrier. AGEs administration induced an-regulation of Abeta production, inflammation, and oxidative stress, and an increased escape latency of rats in the Morris water maze test, all of these are significantly reduced by FPS-ZM1 treatment. FPS-ZM1 might be a novel therapeutic agent to treat AD patients. 

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