FIIN-3
编号: 16122945
Cas号: 1637735-84-2
纯度: 98%
FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R. (Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.)
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | FIIN-3 |
|---|---|
| Iupac 化学名称 | FIIN-3 |
| 同义词 | FIIN3; FIIN 3 |
| 英文同义词 | FIIN3; FIIN 3 |
| 分子式 | C34H36Cl2N8O4 |
| 分子量 | 691.60684 |
| InChiKey | |
| InChi | |
| Cas号 | 1637735-84-2 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
