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FIIN-3

编号: 16122945
Cas号: 1637735-84-2
纯度: 98% 

FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R. (Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.) 

仅供研究使用。 我们不向患者出售。

化学信息

名称FIIN-3
Iupac 化学名称FIIN-3 
同义词FIIN3; FIIN 3 
英文同义词FIIN3; FIIN 3 
分子式C34H36Cl2N8O4 
分子量691.60684 
InChiKey
InChi
Cas号1637735-84-2
相关CAS号

订购信息

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外观性状crystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122945 - FIIN-3 | CAS 1637735-84-2

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