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FH535

Catalog No.: 16122788
Cas No.: 108409-83-2
Purity : 98% 

FH535 is a Wnt/-catenin signaling inhibitor and also a dual PPAR and PPAR antagonist.FH535 antagonizes -Catenin/TcfCmediated transcription, and inhibits recruitment of the coactivators GRIP1 and -catenin to PPAR and PPAR. FH535 shows selective anti-proliferation effect on some cancer cells expressing high or active Wnt/-catenin pathway. [1] FH535 increases cigarette smoke condensate cytotoxicity, and causes changes in -catenin and EGR-1 signaling. [2] FH535 has potential therapeutic value in treatment of liver cancer by targeting liver cancer stem cells and hepatocellular carcinoma cell lines.  

For research use only. We do not sell to patients.

Chemical Information

名称FH535
Iupac 化学名称FH535 
同义词N/A 
英文同义词N/A 
分子式C13H10Cl2N2O4S 
分子量361.2 
SmileCc1cc(ccc1NS(=O)(=O)c2cc(ccc2Cl)Cl)[N+](=O)[O-]
InChiKeyAXNUEXXEQGQWPA-UHFFFAOYSA-N
InChiInChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
Cas号108409-83-2
MDLMFCD01212888
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Ordering Information

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Formulationcrystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122788 - FH535 | CAS 108409-83-2

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