FG-2216, also known as YM311, is orally bioavailable HIF-prolyl hydroxylase inhibitor. FG-2216 induced significant and reversible Epo induction in vivo. FG-2216 showed the ability to stabilize HIF-, to stimulate EPO secretion in in vitro studies, and to increase hematocrit, red blood cell count, and hemoglobin levels in an animal efficacy study.
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化学信息
| 名称 | FG-2216 |
| Iupac 化学名称 | FG-2216 |
| 同义词 | FG 2216; FG2216; YM311; YM-311; YM 311 |
| 英文同义词 | FG 2216; FG2216; YM311; YM-311; YM 311 |
| 分子式 | C12H9ClN2O4 |
| 分子量 | 280.664 |
| Smile | c1ccc2c(c1)c(c(nc2Cl)C(=O)NCC(=O)O)O |
| InChiKey | OUQVKRKGTAUJQA-UHFFFAOYSA-N |
| InChi | InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) |
| Cas号 | 223387-75-5 |
| MDL | MFCD23136998 |
| 相关CAS号 | |
| 外观性状 | crystalline solid |
| 纯度 | 98% |
| 存储 | 3 years -20ºCpowder |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
| 海关编码 | |
| Targets | |
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |