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Ertiprotafib

Catalog No.: 16122942
Cas No.: 251303-04-5
Purity : 98% 
16122942 - Ertiprotafib | CAS 251303-04-5

Catalog number : 16122942

CAS number : 251303-04-5

分子式 : C31H27BrO3S 

分子量 : 559.52 

Iupac 化学名称 : (2R)-2-(4-(9-bromo-2,3-dimethylnaphtho(2,3-b)thiophen-4-yl)-2,6-dimethylphenoxy)-3-phenylpropionic acid 

Smile : BrC1=C2C=CC=CC2=C(C2=C1SC(=C2C)C)C2=CC(=C(O[C@@H](C(=O)O)CC1=CC=CC=C1)C(=C2)C)C

InChiKey : FONCZICQWCUXEB-RUZDIDTESA-N

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同义词PTP-112; PTP112; PTP 112 
英文同义词PTP-112; PTP112; PTP 112 
分子式C31H27BrO3S 
分子量559.52 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileBrC1=C2C=CC=CC2=C(C2=C1SC(=C2C)C)C2=CC(=C(O[C@@H](C(=O)O)CC1=CC=CC=C1)C(=C2)C)C
InChiKeyFONCZICQWCUXEB-RUZDIDTESA-N
InChiInChI=1S/C31H27BrO3S/c1-17-14-22(15-18(2)29(17)35-25(31(33)34)16-21-10-6-5-7-11-21)27-23-12-8-9-13-24(23)28(32)30-26(27)19(3)20(4)36-30/h5-15,25H,16H2,1-4H3,(H,33,34)/t25-/m1/s1
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Ertiprotafib, also known as PTP-112, is a Protein Tyrosine Phosphatase 1B Inhibitor (PTP1B inhibitor). Ertiprotafib normalized the plasma glucose and insulin levels in diabetic animal models, and progressed to a phase II clinical trial. Ertiprotafib is potentially useful for the treatment of Non-Insulin Dependent Diabetes. Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms. Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta), with an IC(50) of 400nM. 

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