Eptapirone, also known as F11440, is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone.
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化学信息
| 名称 | Eptapirone |
| Iupac 化学名称 | Eptapirone |
| 同义词 | F11440; F-11440; F 11440; Eptapirone; L0068; L-0068; L 0068 |
| 英文同义词 | F11440; F-11440; F 11440; Eptapirone; L0068; L-0068; L 0068 |
| 分子式 | C16H23N7O2 |
| 分子量 | 345.407 |
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| Cas号 | 179756-85-5 |
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| 外观性状 | crystalline solid |
| 纯度 | 98% |
| 存储 | 3 years -20ºCpowder |
| 可溶性 | Soluble in DMSO |
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| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
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