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Elesclomol

Catalog No.: 16071025
Cas No.: 488832-69-5
Purity : 98% by HPLC 
16071025 - Elesclomol | CAS 488832-69-5

Catalog number : 16071025

CAS number : 488832-69-5

分子式 : C19H20N4O2S2 

分子量 : 400.52 

Iupac 化学名称 : N'1,N'3-dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide 

Smile : CN(NC(CC(=O)NN(C(=S)C1=CC=CC=C1)C)=O)C(=S)C1=CC=CC=C1

InChiKey : BKJIXTWSNXCKJH-UHFFFAOYSA-N

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同义词STA4783; STA-4783 
英文同义词STA4783; STA-4783 
分子式C19H20N4O2S2 
分子量400.52 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCN(NC(CC(=O)NN(C(=S)C1=CC=CC=C1)C)=O)C(=S)C1=CC=CC=C1
InChiKeyBKJIXTWSNXCKJH-UHFFFAOYSA-N
InChiInChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)
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Elesclomol, also known as STA-4783, is a HSP-90 Inhibitor, and is a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative stress beyond baseline levels elevates ROS beyond sustainable levels, exhausting tumor cell antioxidant capacity, which may result in the induction of the mitochondrial apoptosis pathway.  

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