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EXP-3174

编号: 16122943
Cas号: 124750-92-1
纯度: 98% 

EXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, EXP-3174 is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. 

仅供研究使用。 我们不向患者出售。

化学信息

名称EXP-3174
Iupac 化学名称EXP-3174 
同义词EXP 3174; EXP3174; E-3174; E 3174; E3174; Losartan Carboxylic Acid 
英文同义词EXP 3174; EXP3174; E-3174; E 3174; E3174; Losartan Carboxylic Acid 
分子式C22H21ClN6O2 
分子量436.9 
Smile[2H]c1c(c(c(c(c1Cn2c(nc(c2C(=O)O)Cl)CCCC)[2H])[2H])c3ccccc3c4[nH]nnn4)[2H]
InChiKeyZEUXAIYYDDCIRX-IRYCTXJYSA-N
InChiInChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)/i9D,10D,11D,12D
Cas号124750-92-1
MDLMFCD08063458
相关CAS号

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外观性状crystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122943 - EXP-3174 | CAS 124750-92-1

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