ETP-46321
编号: 611825
Cas号: 1252594-99-2
纯度: 98%
ETP-46321 is a potent and orally bioavailable PI3K / inhibitor with IC50 of 2.3/14.2 nM for p110/p110; exhibits potency on mutated p110(IC50=1.77-2.33 nM, p110a E542K; E545K; H1047R).
ETP-46321, has been pro?led and shown to be a potent PI3K a and d inhibitor, highly selective versus mTOR and 288 representative kinases. The compound demonstrated a good pharmacokinetic profile in mice and was selected for preliminary in vivo evaluation in a lung tumor mouse model driven by a K-Ras G12V oncogenic mutation, showing significant tumor growth inhibition (ca. 51%), and reduction of the tumor metabolic activity as measured by PET techniques.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | ETP-46321 |
|---|---|
| Iupac 化学名称 | ETP-46321 |
| 同义词 | ETP 46321; ETP46321 |
| 英文同义词 | ETP 46321; ETP46321 |
| 分子式 | C20H27N9O3S |
| 分子量 | 473.55 |
| InChiKey | |
| InChi | |
| Cas号 | 1252594-99-2 |
| 相关CAS号 |
订购信息
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