EPZ020411
编号: 16090201
Cas号: 1700663-41-7
纯度: 98% by HPLC
EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has 10 fold selectivity for PRMT6 over PRMT1 and PRMT8.
IC50 value: 10 nM
Target: PRMT6
in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.
in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.
IC50 value: 10 nM
Target: PRMT6
in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells.
in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | EPZ020411 |
|---|---|
| Iupac 化学名称 | N1,N2-dimethyl-N1-((3-(4-((1r,3r)-3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine |
| 同义词 | HY-12970 |
| 英文同义词 | HY-12970 |
| 分子式 | C25H38N4O3 |
| 分子量 | 442.59 |
| InChiKey | |
| InChi | |
| Cas号 | 1700663-41-7 |
| 相关CAS号 |
订购信息
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