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EPZ-6438

Catalog No.: 52302
Cas No.: 1403254-99-8
Purity : 98% 
52302 - EPZ-6438 | CAS 1403254-99-8

Catalog number : 52302

CAS number : 1403254-99-8

分子式 : C34H44N4O4 

分子量 : 572.74 

Iupac 化学名称 : [1,1'-Biphenyl]-3-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl-4'-(4-morpholinylmethyl)- 

Smile : O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O

InChiKey : NSQSAUGJQHDYNO-UHFFFAOYSA-N

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同义词EPZ-6438 
英文同义词EPZ-6438 
分子式C34H44N4O4 
分子量572.74 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileO=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
InChiKeyNSQSAUGJQHDYNO-UHFFFAOYSA-N
InChiInChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
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EPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs. 

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