EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase with Ki of 80 pM; demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor.
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化学信息
| 名称 | EPZ-5676 |
| 分子式 | C30H42N8O3 |
| 分子量 | 562.71 |
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| InChi | |
| Cas号 | 1380288-87-8 |
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| 纯度 | 98% |
| 可溶性 | DMSO 100 mg/ml; Water <1 mg/ml |
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