EN460
EN460 is an endoplasmic reticulum oxidoreductase (ERO1) inhibitor. EN460 showed a dose response effect on the embryos with a dose of 10 μM being significantly lethal during early embryonic development.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | EN460 |
|---|---|
| Iupac 化学名称 | (Z)-2-chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid |
| 同义词 | EN460; EN-460; EN 460. |
| 英文同义词 | EN460; EN-460; EN 460. |
| 分子式 | C22H12ClF3N2O4 |
| 分子量 | 460.79 |
| Smile | O=C(O)C1=CC(N2N=C(C(F)(F)F)/C(C2=O)=C/C3=CC=C(C4=CC=CC=C4)O3)=CC=C1Cl |
| InChiKey | RSLFQCNAOMQAIH-WJDWOHSUSA-N |
| InChi | InChI=1S/C22H12ClF3N2O4/c23-17-8-6-13(10-15(17)21(30)31)28-20(29)16(19(27-28)22(24,25)26)11-14-7-9-18(32-14)12-4-2-1-3-5-12/h1-11H,(H,30,31)/b16-11- |
| Cas号 | 496807-64-8 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Blais JD, Chin KT, Zito E, Zhang Y, Heldman N, Harding HP, Fass D, Thorpe C, Ron D. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003. doi: 10.1074/jbc.M110.126599. PubMed PMID: 20442408; PubMed Central PMCID: PMC2898301.
2. High-content screen using Zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor
In Press, Accepted Manuscript, Available online 28 February 2017
Werner J. Geldenhuys, Sadie A. Bergeron, Jackie E. Mullins, Rowaa Aljammal, Briah L. Gaasch, Wei-Chi Chen, June Yun, Lori A. Hazlehurst
