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Dovitinib

Catalog No.: 16071106
Cas No.: 405169-16-6
Purity : 98% by HPLC 
16071106 - Dovitinib | CAS 405169-16-6

Catalog number : 16071106

CAS number : 405169-16-6

分子式 : C24H27FN6O4 

分子量 : 482.51 

Iupac 化学名称 : 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-hydroxypropanoate 

Smile : OC(C(=O)O)C.NC1=C(C(NC2=CC=CC(=C12)F)=O)C1=NC2=C(N1)C=C(C=C2)N2CCN(CC2)C

InChiKey : ZRHDKBOBHHFLBW-UHFFFAOYSA-N

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同义词TKI258; TKI-258 
英文同义词TKI258; TKI-258 
分子式C24H27FN6O4 
分子量482.51 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileOC(C(=O)O)C.NC1=C(C(NC2=CC=CC(=C12)F)=O)C1=NC2=C(N1)C=C(C=C2)N2CCN(CC2)C
InChiKeyZRHDKBOBHHFLBW-UHFFFAOYSA-N
InChiInChI=1S/C21H21FN6O.C3H6O3/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29);2,4H,1H3,(H,5,6)
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 Dovitinib, also known as TKI-258 or CHIR-258, is an orally bioavailable FGFR3 inhibitor, which strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell death. In addition, this agent may inhibit other members of the RTK superfamily, including the vascular endothelial growth factor receptor; fibroblast growth factor receptor 1; platelet-derived growth factor receptor type 3; FMS-like tyrosine kinase 3; stem cell factor receptor (c-KIT); and colony-stimulating factor receptor 1; this may result in an additional reduction in cellular proliferation and angiogenesis, and the induction of tumor cell apoptosis. 

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