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Dolutegravir Sodium

Catalog No.: 16122764
Cas No.: 1051375-19-9
Purity : 98% 
16122764 - Dolutegravir Sodium | CAS 1051375-19-9

Catalog number : 16122764

CAS number : 1051375-19-9

分子式 : C20H19F2N3O5.Na 

分子量 : 441.36 

Iupac 化学名称 : Dolutegravir Sodium 

Smile : FC1=C(CNC(=O)C=2C(C(=C3N(C[C@@H]4OCC[C@H](N4C3=O)C)C2)[O-])=O)C=CC(=C1)F.[Na+]

InChiKey : UGWJRRXTMKRYNK-VSLILLSYSA-M

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同义词GSK-1349572A 
英文同义词GSK-1349572A 
分子式C20H19F2N3O5.Na 
分子量441.36 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileFC1=C(CNC(=O)C=2C(C(=C3N(C[C@@H]4OCC[C@H](N4C3=O)C)C2)[O-])=O)C=CC(=C1)F.[Na+]
InChiKeyUGWJRRXTMKRYNK-VSLILLSYSA-M
InChiInChI=1S/C20H19F2N3O5.Na/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22;/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28);/q;+1/p-1/t10-,15+;/m1./s1
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Dolutegravir is a HIV integrase inhibitor with IC50 of 2.7 nM.Dolutegravir(S/GSK1349572) inhibits HIV-1 integrase-catalyzed strand transfer with a 50% inhibitory concentration (IC50) of 2.7 nM. S/GSK1349572 inhibits both the HIV integration reaction strand transfer step in vitro and HIV replication in cells with similar potencies. The inhibitor has no effect on total viral DNA synthesis in infected cells but blocks the integration of viral DNA into host DNA with the same potency as its antiviral effect 

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