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Defactinib

Catalog No.: 16122929
Cas No.: 1073160-26-5
Purity : 98% 
16122929 - Defactinib | CAS 1073160-26-5

Catalog number : 16122929

CAS number : 1073160-26-5

分子式 : C20H22ClF3N8O3S 

分子量 : 546.9542 

Iupac 化学名称 : 1073160-26-5 

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同义词Defactinib hydrochloride; Defactinib HCl; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878; PF4554878 
英文同义词Defactinib hydrochloride; Defactinib HCl; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878; PF4554878 
分子式C20H22ClF3N8O3S 
分子量546.9542 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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Defactinib, also known as VS-6063 and PF04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Defactinib inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including those involving RAS/MEK/ERK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation, survival, and tumor angiogenesis. 

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