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Debio-1347

Catalog No.: 16122928
Cas No.: 1265229-25-1
Purity : 98% 
16122928 - Debio-1347 | CAS 1265229-25-1

Catalog number : 16122928

CAS number : 1265229-25-1

分子式 : C20H16N6O 

分子量 : 356.38 

Iupac 化学名称 : Debio-1347 

Smile : NC1=C(C=NN1C1=CC2=C(N=C(N2)C)C=C1)C(=O)C=1NC2=CC=CC=C2C1

InChiKey : BEMNJULZEQTDJY-UHFFFAOYSA-N

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同义词Debio 1347; Debio1347; CH5183284; CH 5183284; CH-5183284; FF284; FF-284; FF 284 
英文同义词Debio 1347; Debio1347; CH5183284; CH 5183284; CH-5183284; FF284; FF-284; FF 284 
分子式C20H16N6O 
分子量356.38 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileNC1=C(C=NN1C1=CC2=C(N=C(N2)C)C=C1)C(=O)C=1NC2=CC=CC=C2C1
InChiKeyBEMNJULZEQTDJY-UHFFFAOYSA-N
InChiInChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)
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Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. 

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