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Darinaparsin

编号: 16122927
Cas号: 69819-86-9
纯度: 98% 

Darinaparsin, also know as ZIO-101 is a small-molecule organic arsenical with potential antineoplastic activity. Although the exact mechanism of action is unclear, darinaparsin, a highly toxic metabolic intermediate of inorganic arsenicals (iAs) that occurs in vivo, appears to generate volatile cytotoxic arsenic compounds when glutathione (GSH) concentrations are low. The arsenic compounds generated from darinaparsin disrupt mitochondrial bioenergetics, producing reactive oxygen species (ROS) and inducing ROS-mediated tumor cell apoptosis; in addition, this agent or its byproducts may initiate cell death by interrupting the G2/M phase of the cell cycle and may exhibit antiangiogenic effects. 

仅供研究使用。 我们不向患者出售。

化学信息

名称Darinaparsin
Iupac 化学名称Darinaparsin 
同义词ZIO 101; ZIO101; ZIO-101. Darinaparsin; Zinapar 
英文同义词ZIO 101; ZIO101; ZIO-101. Darinaparsin; Zinapar 
分子式C12H22AsN3O6S 
分子量411.31 
SmileC[As](C)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
InChiKeyJGDXFQORBMPJGR-YUMQZZPRSA-N
InChiInChI=1S/C12H22AsN3O6S/c1-13(2)23-6-8(11(20)15-5-10(18)19)16-9(17)4-3-7(14)12(21)22/h7-8H,3-6,14H2,1-2H3,(H,15,20)(H,16,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1
Cas号69819-86-9
MDLMFCD17215931
相关CAS号

订购信息

包装价格库存纯度备货期
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外观性状crystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. 
海关编码
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122927 - Darinaparsin | CAS 69819-86-9

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