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Darinaparsin

Catalog No.: 16122927
Cas No.: 69819-86-9
Purity : 98% 
16122927 - Darinaparsin | CAS 69819-86-9

Catalog number : 16122927

CAS number : 69819-86-9

分子式 : C12H22AsN3O6S 

分子量 : 411.31 

Iupac 化学名称 : Darinaparsin 

Smile : C[As](C)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N

InChiKey : JGDXFQORBMPJGR-YUMQZZPRSA-N

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同义词ZIO 101; ZIO101; ZIO-101. Darinaparsin; Zinapar 
英文同义词ZIO 101; ZIO101; ZIO-101. Darinaparsin; Zinapar 
分子式C12H22AsN3O6S 
分子量411.31 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileC[As](C)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
InChiKeyJGDXFQORBMPJGR-YUMQZZPRSA-N
InChiInChI=1S/C12H22AsN3O6S/c1-13(2)23-6-8(11(20)15-5-10(18)19)16-9(17)4-3-7(14)12(21)22/h7-8H,3-6,14H2,1-2H3,(H,15,20)(H,16,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1
MDLMFCD17215931
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Darinaparsin, also know as ZIO-101 is a small-molecule organic arsenical with potential antineoplastic activity. Although the exact mechanism of action is unclear, darinaparsin, a highly toxic metabolic intermediate of inorganic arsenicals (iAs) that occurs in vivo, appears to generate volatile cytotoxic arsenic compounds when glutathione (GSH) concentrations are low. The arsenic compounds generated from darinaparsin disrupt mitochondrial bioenergetics, producing reactive oxygen species (ROS) and inducing ROS-mediated tumor cell apoptosis; in addition, this agent or its byproducts may initiate cell death by interrupting the G2/M phase of the cell cycle and may exhibit antiangiogenic effects. 

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