Daprodustat (Synonyms: GSK1278863)
Daprodustat (Synonyms: GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
Daprodustat (GSK1278863), Bulk in stock, contact us by email for Bulk quotation. Kg scale intermediates are also be provided by custom synthesis.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Daprodustat (Synonyms: GSK1278863) |
|---|---|
| Iupac 化学名称 | (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine |
| 同义词 | GSK1278863; GSK 1278863; GSK-1278863; Daprodustat |
| 英文同义词 | GSK1278863; GSK 1278863; GSK-1278863; Daprodustat |
| 分子式 | C19H27N3O6 |
| 分子量 | 393.43 |
| Smile | C1(CCCCC1)N1C(N(C(C(C1=O)C(=O)NCC(=O)O)=O)C1CCCCC1)=O |
| InChiKey | RUEYEZADQJCKGV-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24) |
| Cas号 | 960539-70-2 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色至白色固体 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期可在0-4度保存，数天至数月；长期可在-20度保存三年。 |
| 可溶性 | 可溶于DMSO；不溶于水 |
| 处理方式 | |
| 运输条件 | 可在常温下运输 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
[1]. Brigandi RA, et al. A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial. Am J Kidney Dis. 2016 Jun;67(6):861-71
[2]. Hara K, et al. Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8
