Danoprevir
编号: 16070107
Cas号: 850876-88-9
纯度: 98% by HPLC
Danoprevir, also known as ITMN-191 and RG-7227, is under development by InterMune Inc and Roche Holding AG, is a promising, potent NS3/4A protease inhibitor for the oral treatment of HCV infection. Preclinical data demonstrated that danoprevir binds with high affinity and dissociates slowly from the HCV NS3 protease, allowing high liver drug exposure with only modest plasma drug exposure. A phase Ib, 'IFN-free' clinical trial demonstrated that danoprevir, combined with the HCV polymerase inhibitor RG-7128 (Pharmasset Inc/Roche Holding AG), was effective in reducing HCV-RNA levels in a large proportion of treatment-naÃve patients with HCV infection and in approximately half of previously non-responsive patients with HCV-1 infection, without resistance or safety concerns.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Danoprevir |
|---|---|
| Iupac 化学名称 | (2R,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate |
| 同义词 | RG7227; RG 7227; |
| 英文同义词 | RG7227; RG 7227; |
| 分子式 | C35H46FN5O9S |
| 分子量 | 731.83 |
| Smile | FC1=C2CN(CC2=CC=C1)C(=O)O[C@@H]1C[C@@H]2N(C(C(CCCCC\C=C/[C@H]3[C@](NC2=O)(C3)C(NS(=O)(=O)C3CC3)=O)NC(=O)OC(C)(C)C)=O)C1 |
| InChiKey | ZVTDLPBHTSMEJZ-QIFYYAQYSA-N |
| InChi | InChI=1S/C35H46FN5O9S/c1-34(2,3)50-32(45)37-27-13-8-6-4-5-7-11-22-17-35(22,31(44)39-51(47,48)24-14-15-24)38-29(42)28-16-23(19-41(28)30(27)43)49-33(46)40-18-21-10-9-12-26(36)25(21)20-40/h7,9-12,22-24,27-28H,4-6,8,13-20H2,1-3H3,(H,37,45)(H,38,42)(H,39,44)/b11-7-/t22-,23-,27?,28+,35-/m1/s1 |
| Cas号 | 850876-88-9 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
