DS-6051B adipate
编号: 211153
Cas号: 1505515-69-4
纯度: 98% Min.
DS-6051B is an orally available inhibitor of the receptor tyrosine kinases C-ros oncogene 1 (ROS1) and the neurotrophic tyrosine receptor kinase (NTRK) types 1, 2 and 3, with potential antineoplastic activity. Upon oral administration, DS-6051b binds to and inhibits ROS1 and the NTRK family members. This inhibition leads to a disruption of ROS1- and NTRK-mediated signaling and eventually inhibits the growth of tumor cells that are overexpressing ROS1 and/or NTRKs. ROS1, overexpressed in certain cancer cells, plays a key role in cell growth and survival of cancer cells. NTRK mutations or rearrangements play a key role in cancer progression.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | DS-6051B adipate |
|---|---|
| Iupac 化学名称 | 3-[4-[((2R)-2-Aminopropyl)oxy]phenyl]-N-[(1R)-1-(3-fluorophenyl)ethyl]imidazo[1,2-b]pyridazin-6-amine monoadipate |
| 同义词 | DS-6051B; DS 6051B; DS6051B. |
| 英文同义词 | DS-6051B; DS 6051B; DS6051B. |
| 分子式 | C29H34FN5O5 |
| 分子量 | 551.6194 |
| Smile | C[C@@H](NC1=NN2C(C=C1)=NC=C2C3=CC=C(OC[C@H](N)C)C=C3)C4=CC=CC(F)=C4.O=C(O)CCCCC(O)=O |
| InChiKey | DORJQZDOULKINH-QNBGGDODSA-N |
| InChi | InChI=1S/C23H24FN5O.C6H10O4/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18;7-5(8)3-1-2-4-6(9)10/h3-13,15-16H,14,25H2,1-2H3,(H,27,28);1-4H2,(H,7,8)(H,9,10)/t15-,16-;/m1./s1 |
| Cas号 | 1505515-69-4 |
| 相关CAS号 |
订购信息
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