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DCC-2036(Rebastinib)

Catalog No.: 52023
Cas No.: 1020172-07-9
Purity : 98%

Rebastinib(DCC-2036;DCC2036) is an inhibitor of tyrosine kinases TIE2 and ABL1.Rebastinib(DCC2036) can prevent primary tumor growth and lung metastasis in the PyMT breast cancer model.  Rebastinib is approximately 50 times more potent as an inhibitor of TIE2 than BCR-ABL. 

For research use only. We do not sell to patients.

Chemical Information

名称DCC-2036(Rebastinib)
Iupac 化学名称1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea 
同义词DCC-2036,Rebastinib;DCC2036;DCC 2036 
英文同义词DCC-2036, Rebastinib, DCC2036, DCC 2036 
分子式C30H28FN7O3 
分子量553.59 
SmileC(C)(C)(C)C1=NN(C(=C1)NC(=O)NC1=C(C=C(C=C1)OC1=CC(=NC=C1)C(NC)=O)F)C=1C=C2C=CC=NC2=CC1
InChiKeyWVXNSAVVKYZVOE-UHFFFAOYSA-N
InChiInChI=1S/C30H28FN7O3/c1-30(2,3)26-17-27(38(37-26)19-7-9-23-18(14-19)6-5-12-33-23)36-29(40)35-24-10-8-20(15-22(24)31)41-21-11-13-34-25(16-21)28(39)32-4/h5-17H,1-4H3,(H,32,39)(H2,35,36,40)
Cas号1020172-07-9
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Ordering Information

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Formulationoff-white solid 
纯度98%
存储3 years -20ºCpowder 6 months-80ºCin solvent 
可溶性5mg/ml in DMSO 
Handling
运输条件Shipped under ambient temperature 
HS Code2933290090
TargetsRebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1WT and Abl1T315I with IC50 of 0.8 nM and 4 nM, also inhibits SRC, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit.
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

52023 - DCC-2036(Rebastinib) | CAS 1020172-07-9

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