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Cytosporone B

Catalog No.: 16122924
Cas No.: 321661-62-5
Purity : 98% 
16122924 - Cytosporone B | CAS 321661-62-5

Catalog number : 16122924

CAS number : 321661-62-5

分子式 : C18H26O5 

分子量 : 322.4 

Iupac 化学名称 : Cytosporone B 

Smile : CCCCCCCC(=O)c1c(cc(cc1O)O)CC(=O)OCC

InChiKey : UVVWQQKSNZLUQA-UHFFFAOYSA-N

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同义词N/A 
英文同义词N/A 
分子式C18H26O5 
分子量322.4 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileCCCCCCCC(=O)c1c(cc(cc1O)O)CC(=O)OCC
InChiKeyUVVWQQKSNZLUQA-UHFFFAOYSA-N
InChiInChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
MDLMFCD12912406
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Cytosporone B is the first naturally occurring agonist for nuclear orphan receptor Nur77. The molecule binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is also involved in glucose homeostasis, where it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth. 

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