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Ciliobrevin A

Catalog No.: 16122921
Cas No.: 302803-72-1
Purity : 98% 
16122921 - Ciliobrevin A | CAS 302803-72-1

Catalog number : 16122921

CAS number : 302803-72-1

分子式 : C17H9Cl2N3O2 

分子量 : 358.178 

Iupac 化学名称 : Ciliobrevin A 

Smile : c1ccc2c(c1)C(=O)N/C(=C(\C#N)/C(=O)c3ccc(cc3Cl)Cl)/N2

InChiKey : SESYPWCSIZUIAS-FOWTUZBSSA-N

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同义词HPI-4; HPI 4; HPI4. Hedgehog Pathway Inhibitor 4 
英文同义词HPI-4; HPI 4; HPI4. Hedgehog Pathway Inhibitor 4 
分子式C17H9Cl2N3O2 
分子量358.178 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
Smilec1ccc2c(c1)C(=O)N/C(=C(\C#N)/C(=O)c3ccc(cc3Cl)Cl)/N2
InChiKeySESYPWCSIZUIAS-FOWTUZBSSA-N
InChiInChI=1S/C17H9Cl2N3O2/c18-9-5-6-10(13(19)7-9)15(23)12(8-20)16-21-14-4-2-1-3-11(14)17(24)22-16/h1-7,21H,(H,22,24)/b16-12+
MDLMFCD01911757
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Ciliobrevin A, also known as HPI-4 and Hedgehog Pathway Inhibitor 4, is a Hedgehog pathway inhibitor. Treatment with HH pathway inhibitor-4 (HPI-4) could significantly decrease human chondrosarcoma cell proliferation, invasion and migration ability. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. HH downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). d HPI-4 could be a new therapeutic option specific to chondrosarcoma expressing elevated levels of HH pathway. 

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