Ciliobrevin A
编号: 16122921
Cas号: 302803-72-1
纯度: 98%
Ciliobrevin A, also known as HPI-4 and Hedgehog Pathway Inhibitor 4, is a Hedgehog pathway inhibitor. Treatment with HH pathway inhibitor-4 (HPI-4) could significantly decrease human chondrosarcoma cell proliferation, invasion and migration ability. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. HH downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). d HPI-4 could be a new therapeutic option specific to chondrosarcoma expressing elevated levels of HH pathway.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Ciliobrevin A |
|---|---|
| Iupac 化学名称 | Ciliobrevin A |
| 同义词 | HPI-4; HPI 4; HPI4. Hedgehog Pathway Inhibitor 4 |
| 英文同义词 | HPI-4; HPI 4; HPI4. Hedgehog Pathway Inhibitor 4 |
| 分子式 | C17H9Cl2N3O2 |
| 分子量 | 358.178 |
| Smile | c1ccc2c(c1)C(=O)N/C(=C(\C#N)/C(=O)c3ccc(cc3Cl)Cl)/N2 |
| InChiKey | SESYPWCSIZUIAS-FOWTUZBSSA-N |
| InChi | InChI=1S/C17H9Cl2N3O2/c18-9-5-6-10(13(19)7-9)15(23)12(8-20)16-21-14-4-2-1-3-11(14)17(24)22-16/h1-7,21H,(H,22,24)/b16-12+ |
| Cas号 | 302803-72-1 |
| MDL | MFCD01911757 |
| 相关CAS号 |
订购信息
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