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Chrysophanic acid

Catalog No.: 161009017
Cas No.: 481-74-3
Purity : 98% by HPLC 
161009017 - Chrysophanic acid | CAS 481-74-3

Catalog number : 161009017

CAS number : 481-74-3

分子式 : C15H10O4 

分子量 : 254.2375 

Iupac 化学名称 : 1,8-dihydroxy-3-methylanthracene-9,10-dione 

Smile : OC1=CC(=CC=2C(C3=CC=CC(=C3C(C12)=O)O)=O)C

InChiKey : LQGUBLBATBMXHT-UHFFFAOYSA-N

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同义词Chrysophanol; Chrysophanic acid 
英文同义词Chrysophanol; Chrysophanic acid 
分子式C15H10O4 
分子量254.2375 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileOC1=CC(=CC=2C(C3=CC=CC(=C3C(C12)=O)O)=O)C
InChiKeyLQGUBLBATBMXHT-UHFFFAOYSA-N
InChiInChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
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Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 Âm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. 

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