Chiauranib
Chiauranib also known as orally available, small molecule inhibitor of select serine-threonine kinases, including aurora kinase B (aurora B), vascular endothelial growth factor receptors (VEGFRs), stem cell factor receptor (c-KIT), and platelet-derived growth factor receptors (PDGFRs), with potential antineoplastic activity. Upon oral administration, chiauranib binds to and inhibits the activity of aurora B, VEGFRs, c-kit and PDGFRs, which may result in a decrease in the proliferation of tumor cells that overexpress these kinases. These kinases are overexpressed by a variety of cancer cell types.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Chiauranib |
|---|---|
| Iupac 化学名称 | N-(2-aminophenyl)-6-((7-methoxyquinolin-4-yl)oxy)-1-naphthamide |
| 同义词 | Chiauranib; CS2164; CS-2164; CS 2164; Ibcasertib |
| 英文同义词 | Chiauranib; CS2164; CS-2164; CS 2164; Ibcasertib |
| 分子式 | C27H21N3O3 |
| 分子量 | 435.47 |
| Smile | O=C(C1=C2C=CC(OC3=CC=NC4=CC(OC)=CC=C43)=CC2=CC=C1)NC5=CC=CC=C5N |
| InChiKey | BRKWREZNORONDU-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H21N3O3/c1-32-18-9-12-22-25(16-18)29-14-13-26(22)33-19-10-11-20-17(15-19)5-4-6-21(20)27(31)30-24-8-3-2-7-23(24)28/h2-16H,28H2,1H3,(H,30,31) |
| Cas号 | 1256349-48-0 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色固体 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 0-4℃，可保存几天到几周；-20℃，可保存 几个月。 |
| 可溶性 | 溶于DMSO等有机溶剂 |
| 处理方式 | |
| 运输条件 | 可以在室温下进行运输。 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Deng M, Shi Y, Chen K, Zhao H, Wang Y, Xie S, Zhao J, Luo Y, Fang Z, Fan Y, Xu
B. CS2164 exerts an antitumor effect against human Non-Hodgkin's lymphomas in
vitro and in vivo. Exp Cell Res. 2018 Aug 15;369(2):356-362. doi:
10.1016/j.yexcr.2018.05.038. Epub 2018 Jun 1. PubMed PMID: 29864401.
2: Zhou Y, Shan S, Li ZB, Xin LJ, Pan DS, Yang QJ, Liu YP, Yue XP, Liu XR, Gao
JZ, Zhang JW, Ning ZQ, Lu XP. CS2164, a novel multi-target inhibitor against
tumor angiogenesis, mitosis and chronic inflammation with anti-tumor potency.
Cancer Sci. 2017 Mar;108(3):469-477. doi: 10.1111/cas.13141. Epub 2017 Mar 7.
PubMed PMID: 28004478; PubMed Central PMCID: PMC5378272.
