Centanafadine, also known as EB-1020, is an adrenergic uptake inhibitor and dopamine uptake inhibitor and serotonin uptake inhibitor. Centanafadine modulates norepinephrine, dopamine and, to a lesser extent, serotonin reuptake in a ratio of 1:6:14, respectively to improve focus, attention and executive function.
仅供研究使用。 我们不向患者出售。
| 名称 | Centanafadine HCl |
|---|---|
| Iupac 化学名称 | (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochoride |
| 同义词 | EB-1020 ; EB 1020 ; EB1020 ; EB-1020 SR ; CTN SR ; Centanafadine |
| 英文同义词 | EB-1020 ; EB 1020 ; EB1020 ; EB-1020 SR ; CTN SR ; Centanafadine |
| 分子式 | C15H16ClN |
| 分子量 | 245.75 |
| Smile | [H][C@@]12CNC[C@]1(C3=CC=C4C=CC=CC4=C3)C2.[H]Cl |
| InChiKey | ACVMJAJGCQUPKX-LIOBNPLQSA-N |
| InChi | InChI=1S/C15H15N.ClH/c1-2-4-12-7-13(6-5-11(12)3-1)15-8-14(15)9-16-10-15;/h1-7,14,16H,8-10H2;1H/t14-,15+;/m1./s1 |
| Cas号 | 923981-14-0 |
| 相关CAS号 | 924012-43-1 (free base) 923981-14-0 (HCl) |
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色至白色固体 |
|---|---|
| 纯度 | ≧98.0% |
| 存储 | 短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 | 2933999701 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Bymaster FP, Golembiowska K, Kowalska M, Choi YK, Tarazi FI. Pharmacological
characterization of the norepinephrine and dopamine reuptake inhibitor EB-1020:
implications for treatment of attention-deficit hyperactivity disorder. Synapse.
2012 Jun;66(6):522-32. doi: 10.1002/syn.21538. Epub 2012 Feb 22. PubMed PMID:
22298359.