Centanafadine ( free base )
Centanafadine (free base) is a dual norepinephrine-dopamine transporter inhibitor used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Centanafadine ( free base ) |
|---|---|
| Iupac 化学名称 | 3-Azabicyclo(3.1.0)hexane, 1-(2-naphthalenyl)-, (1R,5S)- |
| 同义词 | Centanafadine ; EB1020 ; EB-1020 ; EB 1020 |
| 英文同义词 | Centanafadine ; EB1020 ; EB-1020 ; EB 1020 |
| 分子式 | C15H15N |
| 分子量 | 209.29 |
| Smile | [H][C@@]12CNC[C@]1(C3=CC=C4C=CC=CC4=C3)C2 |
| InChiKey | HKHCSWPSUSWGLI-CABCVRRESA-N |
| InChi | InChI=1S/C15H15N/c1-2-4-12-7-13(6-5-11(12)3-1)15-8-14(15)9-16-10-15/h1-7,14,16H,8-10H2/t14-,15+/m1/s1 |
| Cas号 | 924012-43-1 |
| 相关CAS号 | 923981-14-0 ( HCl Salt ) |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Schoretsanitis G, de Leon J, Eap CB, Kane JM, Paulzen M. Clinically Significant Drug-Drug Interactions with Agents for Attention- Deficit/Hyperactivity Disorder. CNS Drugs. 2019 Dec;33(12):1201-1222. doi: 10.1007/s40263-019-00683-7. PMID: 31776871.
2: Nageye F, Cortese S. Beyond stimulants: a systematic review of randomised controlled trials assessing novel compounds for ADHD. Expert Rev Neurother. 2019 Jul;19(7):707-717. doi: 10.1080/14737175.2019.1628640. Epub 2019 Jun 26. PMID: 31167583.
3: Wigal SB, Wigal T, Hobart M, Madera JJ, Baker RA, Kohegyi E, McKinney A, Wilens TE. Safety and Efficacy of Centanafadine Sustained-Release in Adults With Attention-Deficit Hyperactivity Disorder: Results of Phase 2 Studies. Neuropsychiatr Dis Treat. 2020 Jun 8;16:1411-1426. doi: 10.2147/NDT.S242084. PMID: 32606695; PMCID: PMC7292254.
