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Canertinib

Catalog No.: 16122909
Cas No.: 289499-45-2
Purity : 98% 
16122909 - Canertinib | CAS 289499-45-2

Catalog number : 16122909

CAS number : 289499-45-2

分子式 : C24H27Cl3FN5O3 

分子量 : 558.86 

Iupac 化学名称 : Canertinib 

Smile : C=CC(=O)Nc1cc2c(cc1OCCCN3CCOCC3)ncnc2Nc4ccc(c(c4)Cl)F.Cl.Cl

InChiKey : JZZFDCXSFTVOJY-UHFFFAOYSA-N

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同义词CI1033PD183805 
英文同义词CI1033PD183805 
分子式C24H27Cl3FN5O3 
分子量558.86 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileC=CC(=O)Nc1cc2c(cc1OCCCN3CCOCC3)ncnc2Nc4ccc(c(c4)Cl)F.Cl.Cl
InChiKeyJZZFDCXSFTVOJY-UHFFFAOYSA-N
InChiInChI=1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
MDLMFCD09954112
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Canertinib dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents. 

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