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CX-5461

Catalog No.: 52748
Cas No.: 1138549-36-6
Purity : 98% 
52748 - CX-5461 | CAS 1138549-36-6

Catalog number : 52748

CAS number : 1138549-36-6

分子式 : C27H27N7O2S 

分子量 : 513.61 

化学名称 : CX-5461

Smile : Cc1cnc(cn1)CNC(=O)c2c(=O)c3ccc(nc3n4c2sc5c4cccc5)N6CCCN(CC6)C

InChiKey : XGPBJCHFROADCK-UHFFFAOYSA-N

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分子式C27H27N7O2S 
分子量513.61 
纯度98% 
可溶性DMSO <1.2mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL 
SmileCc1cnc(cn1)CNC(=O)c2c(=O)c3ccc(nc3n4c2sc5c4cccc5)N6CCCN(CC6)C
InChiKeyXGPBJCHFROADCK-UHFFFAOYSA-N
InChiInChI=1S/C27H27N7O2S/c1-17-14-29-18(15-28-17)16-30-26(36)23-24(35)19-8-9-22(33-11-5-10-32(2)12-13-33)31-25(19)34-20-6-3-4-7-21(20)37-27(23)34/h3-4,6-9,14-15H,5,10-13,16H2,1-2H3,(H,30,36)
MDLMFCD21609261
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CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. 

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