CVT-313
编号: 16122923
Cas号: 199986-75-9
纯度: 98%
CVT-313 is a potent and selective inhibitor of CDK2 that prevents neointimal proliferation. CVT-313 has an IC50 of 0.5 microM in vitro. Inhibition was competitive with respect to ATP (Ki = 95 nM), and selective CVT-313 had no effect on other, nonrelated ATP-dependent serine/threonine kinases. The growth of mouse, rat, and human cells in culture was also inhibited by CVT-313 with the IC50 for growth arrest ranging from 1.25 to 20 microM. CVT-313 is a promising candidate for evaluation in other disease models related to aberrant cell proliferation.
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化学信息
| 名称 | CVT-313 |
|---|---|
| Iupac 化学名称 | CVT-313 |
| 同义词 | CVT 313; CVT313 |
| 英文同义词 | CVT 313; CVT313 |
| 分子式 | C20H28N6O3 |
| 分子量 | 400.483 |
| Smile | CC(C)n1cnc2c1nc(nc2NCc3ccc(cc3)OC)N(CCO)CCO |
| InChiKey | NQVIIUBWMBHLOZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24) |
| Cas号 | 199986-75-9 |
| MDL | MFCD06411412 |
| 相关CAS号 |
订购信息
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