CLEFMA has anti-proliferative activity in H441 cells. CLEFMA may induce autophagic cell death that was inhibited by specific autophagy inhibitor 3-methyladenine. The results suggest that the potent and novel curcuminoid, CLEFMA, offers an alternative mode of cell death in apoptosis-resistant cancers.
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| 名称 | CLEFMA |
|---|---|
| Iupac 化学名称 | (2z)-4-[(3E,5e)-3,5-bis[(2-chlorophenyl)methylene]-4-oxo-1-piperidinyl]-4-oxo-2-butenoic acid |
| 同义词 | CLEFMA |
| 英文同义词 | CLEFMA |
| 分子式 | C23H17Cl2NO4 |
| 分子量 | 442.29 |
| Smile | ClC1=C(C=CC=C1)\C=C\1/CN(C\C(\C1=O)=C/C1=C(C=CC=C1)Cl)C(\C=C/C(=O)O)=O |
| InChiKey | ABOUDPJRQGWQNW-GGDLZHBGSA-N |
| InChi | InChI=1S/C23H17Cl2NO4/c24-19-7-3-1-5-15(19)11-17-13-26(21(27)9-10-22(28)29)14-18(23(17)30)12-16-6-2-4-8-20(16)25/h1-12H,13-14H2,(H,28,29)/b10-9-,17-11+,18-12+ |
| Cas号 | 1246964-32-8 |
| 相关CAS号 | 1246964-32-8 |
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 黄色固体 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years) |
| 可溶性 | 可溶解在DMSO中 |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |