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CHZ868(CHZ-868)

Catalog No.: 72001
Cas No.: 1895895-38-1
Purity : 98% by HPLC 
72001 - CHZ868(CHZ-868) | CAS 1895895-38-1

Catalog number : 72001

CAS number : 1895895-38-1

分子式 : C22H19F2N5O2 

分子量 : 423.42 

Iupac 化学名称 : N-(4-((2-((2,4-difluorophenyl)amino)-1,4-dimethyl-1H-benzo[d]imidazol-5-yl)oxy)pyridin-2-yl)acetamide 

Smile : CN1C2=CC=C(OC3=CC=NC(NC(C)=O)=C3)C(C)=C2N=C1NC4=CC=C(F)C=C4F

InChiKey : KQQLBXFPTDVFAJ-UHFFFAOYSA-N

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同义词CHZ 868;CHZ-868;CHZ868 
英文同义词CHZ 868;CHZ-868;CHZ868 
分子式C22H19F2N5O2 
分子量423.42 
外观crystalline solid 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileCN1C2=CC=C(OC3=CC=NC(NC(C)=O)=C3)C(C)=C2N=C1NC4=CC=C(F)C=C4F
InChiKeyKQQLBXFPTDVFAJ-UHFFFAOYSA-N
InChiInChI=1S/C22H19F2N5O2/c1-12-19(31-15-8-9-25-20(11-15)26-13(2)30)7-6-18-21(12)28-22(29(18)3)27-17-5-4-14(23)10-16(17)24/h4-11H,1-3H3,(H,27,28)(H,25,26,30)
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CHZ868,a type II JAK inhibitor, would demonstrate activity in JAK inhibitor persistent cells, murine MPN models, and MPN patient samples. JAK2 and MPL mutant cell lines were sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 showed significant activity in murine MPN models and induced reductions in mutant allele burden not observed with type I JAK inhibitors. These data demonstrate that type II JAK inhibition is a viable therapeutic approach for MPN patients.
 

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